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- Title
The Controversial Role of Vitamin D in Thyroid Cancer Prevention.
- Authors
Palanca, Ana; Ampudia-Blasco, Francisco Javier; Real, José T.
- Abstract
Thyroid cancer is the most common endocrine malignancy and exhibits rising incidence. Annual incidence varies by sex, age, and geographical location. It has been reported that impairment of vitamin D signalling promotes thyroid cancer progression. Recent studies have shown that vitamin D, a fat-soluble vitamin that acts as both a nutrient and a hormone, may have utility in the prevention of autoimmune thyroid-related diseases. However, the precise role of vitamin D in the pathobiology of thyroid cancer is controversial. Previous studies have suggested that elevated serum vitamin D levels have a protective role in thyroid cancer. However, there is also evidence demonstrating no inverse relationship between vitamin D levels and the occurrence of thyroid cancer. Furthermore, recent data provide evidence that circulating vitamin D concentration is inversely correlated with disease aggressiveness and poor prognosis, while evidence of an association with tumour initiation remains weak. Nevertheless, a variety of data support an anti-tumorigenic role of vitamin D and its potential utility as a secondary chemopreventive agent. In this review, we highlighted recent findings regarding the association of vitamin D status with the risk of thyroid cancer, prognosis, potential mechanisms, and possible utility as a chemopreventive agent.
- Subjects
BLOOD serum analysis; AUTOIMMUNE disease prevention; THERAPEUTIC use of vitamin D; DISEASE progression; THYROID diseases; THYROID gland tumors; ANTINEOPLASTIC agents; VITAMIN D; RISK assessment; CELLULAR signal transduction; CHEMOPREVENTION; DISEASE risk factors
- Publication
Nutrients, 2022, Vol 14, Issue 13, p2593
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14132593