We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades.
- Authors
Villanueva, Mónica; Oyarzún, Amaya; Leyton, Bárbara; González, Mónica; Navarro, Elizabeth; Canales, Paulina; Ossa, Cristobal; Muñoz, María Paz; Bascuñán, Karla A.; Araya, Magdalena
- Abstract
The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994–2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet.
- Subjects
CHILE; CELIAC disease diagnosis; MALNUTRITION; AGE distribution; AGE factors in disease; CELIAC disease; CHILDREN'S hospitals; FAILURE to thrive syndrome; MEDICAL records; OBESITY; RETROSPECTIVE studies; NUTRITIONAL status; ACQUISITION of data methodology; SYMPTOMS
- Publication
Nutrients, 2020, Vol 12, Issue 1, p156
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12010156