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- Title
Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs.
- Authors
Nordgren, Tara M.; Anderson Berry, Ann; Van Ormer, Matthew; Zoucha, Samuel; Elliott, Elizabeth; Johnson, Rebecca; McGinn, Elizabeth; Cave, Caleb; Rilett, Katherine; Weishaar, Kara; Maddipati, Sai Sujana; Appeah, Harriet; Hanson, Corrine
- Abstract
Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 fatty acids serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory and immune-stimulating effects. The role SPM play in the protection against negative maternal-fetal health outcomes is unclear, and there are no current biomarkers of n-3 fatty acid sufficiency. We sought to ascertain the relationships between n-3 fatty acid intake, SPM levels, and maternal-fetal health outcomes. We obtained n-3 fatty acid intake information from 136 mothers admitted for delivery using a food frequency questionnaire and measured docosahexaenoic acid (DHA)-derived SPMs resolvin D1 (RvD1) and RvD2 in maternal and cord plasma. We found significantly elevated SPM in maternal versus cord plasma, and increased SPM levels were associated with at-risk outcomes. We also identified that increased DHA intake was associated with elevated maternal plasma RvD1 (p = 0.03; R2 = 0.18) and RvD2 (p = 0.04; R2 = 0.20) in the setting of neonatal intensive care unit (NICU) admission. These findings indicate that increased n-3 fatty acid intake may provide increased substrate for the production of SPM during high-risk pregnancy/delivery conditions, and that increased maternal plasma SPM could serve as a biomarker for negative neonatal outcomes.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; BIOMARKERS; CORD blood; HIGH-risk pregnancy; LIPIDS; MATERNAL-fetal exchange; EVALUATION of medical care; OMEGA-3 fatty acids; PREGNANCY; PREGNANCY complications; DOCOSAHEXAENOIC acid; DESCRIPTIVE statistics
- Publication
Nutrients, 2019, Vol 11, Issue 1, p98
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11010098