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- Title
Allogeneic marrow transplantation in the treatment of preleukemia.
- Authors
Appelbaum, Frederick R.; Storb, Rainer; Ramberg, Robert E.; Shulman, Howard M.; Buckner, Dean; Clift, Reginald A.; Deeg, H. Joachim; Fefer, Alexander; Sanders, Jean; Stewart, Patricia; Sullivan, Keith; Witherspoon, Robert; Thomas, E. Donnall; Appelbaum, F R; Storb, R; Ramberg, R E; Shulman, H M; Buckner, C D; Clift, R A; Deeg, H J
- Abstract
Ten patients with preleukemia and life-threatening pancytopenia were treated with marrow transplantation. In all ten cases allogeneic marrow was successfully engrafted. In three patients prepared for transplantation with cyclophosphamide alone, the abnormal cell clone either persisted or reemerged within 6 months of transplantation. The other seven patients were treated with cyclophosphamide plus total body irradiation before transplantation and six of the seven are alive and well without evidence of disease from 7 to 25 months after transplantation. These results suggest that cyclophosphamide alone before marrow transplantation is incapable of eradicating the abnormal clone. Cyclophosphamide combined with total body irradiation appears more effective, although more time is needed for full evaluation of results. This experience also emphasizes the importance of performing chromosome studies before transplantation for pancytopenic states in order to identify cases of preleukemia.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; PRELEUKEMIA; LEUKEMIA treatment
- Publication
Annals of Internal Medicine, 1984, Vol 100, Issue 5, p689
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-100-5-689