We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Venetoclax‐based salvage therapy for adult patients with relapsed/refractory acute lymphoblastic leukemia.
- Authors
Canaani, Jonathan; Frisch, Avraham; Pollyea, Daniel A.; Schwartz, Marc; Aumann, Shlomzion; Ganzel, Chezi; Haran, Arnon; Even‐Zohar, Noa Gross; Shaulov, Adir; Vainstein, Vladimir; Moshe, Yakir; Ofran, Yishai; Wolach, Ofir; Nachmias, Boaz
- Abstract
Objectives: Dysregulation of BCL‐2 family members has been reported in acute lymphocytic leukemia (ALL), with various BH3‐dependencies of the leukemic clone. We conducted a multicenter retrospective cohort of patients with relapsed/refractory B or T ALL, with ven‐chemotherapy or ven‐navitoclax combinations, to assess efficacy and safety. Methods: Seventeen patients were included in the analysis, median age was 32 years, with 6 B‐ALL and 11 T‐ALL patients. Nine patients received venetoclax combined with chemotherapy, and 13 patients received venetoclax in combination with navitoclax, vincristine and asparaginase, of which 5 were already exposed to venetoclax in previous lines. Results: ORR was 55% and 46% among the ven‐chemotherapy and the ven‐navitoclax‐chemotherapy, respectively. Most of the responders proceeded to an allogenic bone marrow transplant in both cohorts. The most common adverse effects of the ven‐navitoclax combination were infectious complications and hepatotoxicity. Conclusions: Our data demonstrated the possible efficacy of ven‐chemotherapy and ven‐navitoclax in r/r ALL with moderate toxicity.
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia; SALVAGE therapy; BONE marrow; ADULTS
- Publication
European Journal of Haematology, 2023, Vol 111, Issue 3, p365
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.14015