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- Title
Relationship between native papillary muscle T<sub>1</sub> time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy.
- Authors
Shingo Kato; Shiro Nakamori; Roujol, Sébastien; Delling, Francesca N.; Akhtari, Shadi; Jihye Jang; Basha, Tamer; Berg, Sophie; Kissinger, Kraig V.; Goddu, Beth; Manning, Warren J.; Nezafat, Reza
- Abstract
Background: Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T1 mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. We sought to evaluate the potential relationship between papillary muscle T1 time and mitral regurgitation in DCM patients. Methods: Forty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T1 mapping was performed using a slice interleaved T1 mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation. Results: Papillary muscle T1 time was significantly elevated in DCM patients with mitral regurgitation (n = 22) in comparison to those without mitral regurgitation (n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T1 time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T1 time (β = 0.10, 95 % CI: 0.05-0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction. Elevated papillary muscle T1 time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05). Conclusions: In DCM, papillary muscle native T1 time is significantly elevated and related to mitral regurgitant fraction.
- Subjects
MITRAL valve insufficiency; MUSCLE anatomy; MITRAL valve; CALCIUM antagonists; ADRENERGIC beta agonists; ANALYSIS of variance; ACE inhibitors; ASPIRIN; BLOOD pressure; BLOOD pressure measurement; BODY weight; CHI-squared test; DIAGNOSTIC imaging; DIURETICS; HEART rate monitoring; MAGNETIC resonance imaging; MEDICAL care; PATIENTS; REGRESSION analysis; RESEARCH funding; STATISTICS; STATINS (Cardiovascular agents); DATA analysis; VENTRICULAR remodeling; BODY mass index; CONTROL groups; BODY surface area; DATA analysis software; DILATED cardiomyopathy; ANGIOTENSIN receptors; DESCRIPTIVE statistics; DISEASE complications; ANATOMY; DIAGNOSIS
- Publication
Journal of Cardiovascular Magnetic Resonance (BioMed Central), 2016, p1
- ISSN
1532-429X
- Publication type
Article
- DOI
10.1186/s12968-016-0301-y