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- Title
EVALUATION OF RENIN-ANGIOTENSIN SYSTEM GENES POLYMORPHISMS AND ITS CORELATION WITH PARAOXONASE 1 ACTIVITY IN A HETEROGENOUS GROUP OF HYPERTENSIVE PACIENTS.
- Authors
Popa, Calin; Pilat, Luminta; Ilie, Daniela; Popescu, Cristina
- Abstract
Introduction: The association of polymorphisms of the RAS genes on the incidence of hypertension its still under debate and more over it seems to be population-dependent. Aim: We studied correlations between the angiotensinogen T174M and M235T and angiotensin II receptor 1 (AT1R) A1166C and angiotensin II receptor 2 (AT2R2) C3123A gene polymorphisms and human paraoxonase 1 (PON 1) activity in hypertensive group of patients. Method: 100 patients of a medium and old age have been investigated clinically and subjected to a stress questionnaire. Familial inquiry up to 3rd generation has been recorded. The RFLP-PCR was used to detect the target mutations in RAS genes. Paraoxonase activity was recorded from plasma serum samples. Conclusions: Our results showed strong association of RAS polymorphism with PON1 in a specific study group. We stress out the importance of genetic analysis for essential hypertension and that the possibility of inter-population differences in genetic factors should be kept in mind.
- Subjects
RENIN-angiotensin system; GENETIC polymorphisms; PARAOXONASE; ANGIOTENSIN II; RAS oncogenes; GENETIC mutation
- Publication
Studia Universitatis Vasile Goldis Seria Stiintele Vietii (Life Sciences Series), 2014, p103
- ISSN
1584-2363
- Publication type
Article