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- Title
Body composition and serum levels of matrix metalloproteinase-9, adiponectin and AMP-activated protein kinase in breast cancer survivors.
- Authors
Babaei, Zeinab; Parsian, Hadi; Korani, Bahare; Mostafazadeh, Amrollah; Moslemi, Dariush
- Abstract
Background: Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin and AMP-activated protein kinase (AMPK) levels by comparing serum levels of MMP-9, AMPK in normal weight and obese breast cancer survivors. Materials and Methods: In this cross-sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5-25 kg/m2) and 30 obese breast cancer survivors (BMI ≥30 kg/m2) were investigated. Anthropometric parameters and serum levels of MMP-9, adiponectin, and AMPK were compared between the two groups. Results: No differences were detected in the serum levels of MMP-9, adiponectin, and AMPK in obese patients and normal weight patients (P > 0.05). There were no correlations between MMP-9, adiponectin, and AMPK levels with anthropometric measurements in two groups (P > 0.05). Conclusion: We found that there was a lack of correlation between obesity measures and serum levels of MMP-9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP-9 do not change in obesity state.
- Subjects
BODY composition; PROTEIN kinases; OBESITY; BODY weight; CROSS-sectional method; ANTHROPOMETRY; MATRIX metalloproteinases; CANCER patients; COMPARATIVE studies; ADIPONECTIN; BODY mass index; BREAST tumors
- Publication
Journal of Research in Medical Sciences, 2022, Vol 27, Issue 6, p48
- ISSN
1735-1995
- Publication type
Article
- DOI
10.4103/jrms.JRMS_453_20