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- Title
Palladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond Functionalization.
- Authors
Zhao, Qun; Besset, Tatiana; Poisson, Thomas; Bouillon, Jean‐Philippe; Pannecoucke, Xavier
- Abstract
We report the first introduction of 2-bromo-3,3,3-trifluoropropene (BTP) by directed C-H bond functionalization. The developed method gives straightforward access to α-(trifluoromethyl)styrene derivatives without prior prefunctionalization of the substrates. This palladium-catalysed transformation was applied to a broad range of substrates, and the corresponding trifluoromethylated products were obtained in good yields. This approach represents an alternative pathway to the classical method previously used to access such molecules.
- Subjects
PROPENE; CARBON-hydrogen bonds; STYRENE; PALLADIUM compounds; CATALYSIS research
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 1, p76
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201501217