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- Title
A Strategy for the Triarylation of Pyrrolopyrimidines by Using Microwave-Promoted Cross-Coupling Reactions.
- Authors
Prieur, Vanessa; Pujol, M. Dolors; Guillaumet, Gérald
- Abstract
New pyrrolo[2,3- d]pyrimidines that have aryl groups at the 2-, 4-, and 6-positions were prepared by the arylation reaction of 4-chloro-7-methyl-2-(methylthio)-6-phenylpyrrolo[2,3- d]pyrimidine ( 6) and the corresponding arylboronic acid under Suzuki-Miyaura conditions followed by a second arylation under Liebeskind-Srogl cross-coupling conditions. A parallel study that began with the C-2 chemoselective arylation of 6 under Liebeskind-Srogl conditions followed by a Suzuki-Miyaura coupling at C-4 was carried out, and the results of each route were compared. All of the tranformations were performed under microwave irradiation.
- Subjects
MICROWAVE chemistry; ARYLATION; COUPLING reactions (Chemistry); HETEROCYCLIC compounds; PYRIMIDINES
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 29, p6547
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500625