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- Title
Efficient and Rapid Regioselective One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from In Situ Generated Potassium Arylethynyltrifluoroborates through Sonogashira Reaction.
- Authors
Song, Jung Ho; Choi, Pilju; Lee, Seung Eon; Jeong, Kyu Hyuk; Kim, Taejung; Kang, Ki Sung; Choi, Yong Soo; Ham, Jungyeob
- Abstract
Potassium arylethynyltrifluoroborates, the intermediates generated by the Sonogashira reaction of potassium ethynyltrifluoroborate with various aryl halides, were directly coupled with azides in the presence of a stoichiometric amount of CuI under aqueous conditions, and the desired 1,4-disubstituted 1,2,3-triazoles were isolated in good yields. Both electron-donating and electron-withdrawing substituents on the potassium arylethynyltrifluoroborates gave moderate to excellent yields of the isolated products.
- Subjects
REGIOSELECTIVITY (Chemistry); TRIAZOLES synthesis; POTASSIUM compounds; SONOGASHIRA reaction; ARYL halides; AZIDES; CUPROUS iodide
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 28, p6249
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201301003