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- Title
Synthesis of β-Substituted Porphyrin Derivatives Containing Heterocyclic Moieties as Potential Photosensitizers Against Cutaneous Leishmaniasis.
- Authors
Bastos, Mônica M.; Gomes, Ana T. P. C.; Neves, Maria G. P. M. S.; Silva, Artur M. S.; Santos‐Filho, Osvaldo A.; Boechat, Núbia; Cavaleiro, José A. S.
- Abstract
This work reports the synthesis of porphyrin derivatives with potential leishmanicidal activity. The β-substituents contain amine/imine-heterocyclic features. Molecular docking simulations of these compounds to a model of the enzyme arginase from Leishmania amazonensis were carried out. Singlet oxygen generation studies have been also considered. The obtained leishmanicidal properties show that these compounds can be considered as prototypes for future cutaneous antileishmaniasis agents.
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 8, p1485
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201201501