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- Title
BK VIRUS NEPHROPATHY IN A HEART TRANSPLANT RECIPIENT: THE FIRST DOCUMENTED CASE IN CROATIA.
- Authors
GAVRANIĆ, BRUNA BRUNETTA; BAŠIĆ-JUKIĆ, NIKOLINA; ĆORIĆ, MARIJANA; SKORIĆ, BOŠKO; MILIČIĆ, DAVOR; KES, PETAR
- Abstract
As outcomes following heart transplantation have improved significantly over the last years, chronic kidney disease has become an increasingly prevalent complication in this population. Polyomavirus-associated nephropathy (PVAN) of native kidneys has also been recognized increasingly as a cause of kidney failure. We report the first case of PVAN occurring in the native kidneys of a solid-organ transplant recipient in Croatia as the eighth case described in the literature worldwide. A 65-year-old female with dilatative cardiomyopathy and good kidney function had a heart transplanted in 2012. Initial immunosuppressive therapy consisted of antithymocyte immunoglobulin with cyclosporine, mycophenolate mofetil and corticosteroids. Soon after transplantation, her kidney function began to fail progressively. Biopsy of the native kidneys revealed PVAN, and everolimus was introduced in immunosuppressive therapy. Nevertheless, her renal dysfunction progressed and she is now being evaluated for cadaveric kidney transplantation. PVAN should be considered in the differential diagnosis of new-onset renal failure following non-kidney solid organ transplantation. Early diagnosis is essential for prevention of irreversible renal damage.
- Subjects
CROATIA; BK virus; BK virus diseases; KIDNEY disease risk factors; PUBLIC health; KIDNEY transplant complications; IMMUNOSUPPRESSIVE agents; MYCOPHENOLIC acid; THERAPEUTICS
- Publication
Acta Medica Croatica, 2016, Vol 70, p65
- ISSN
1330-0164
- Publication type
Article