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- Title
Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit.
- Authors
Guidet, Bertrand; Flaatten, Hans; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn H.; Artigas, Antonio; Bertolini, Guido; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Fjølner, Jesper; Jung, Christian; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Pinto, Bernardo Bollen; Soliman, Ivo W.; Szczeklik, Wojciech; Valentin, Andreas
- Abstract
<bold>Purpose: </bold>To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU.<bold>Methods: </bold>This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up.<bold>Results: </bold>LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU length of stay. The ICU and 30-day mortality were, respectively, 29.1 and 53.1% in the withholding group and 82.2% and 93.1% in the withdrawal group. LST was less frequently limited in eastern and southern European countries than in northern Europe. The patient-independent factors associated with LST limitation were: acute ICU admission (OR 5.77, 95% CI 4.32-7.7), Clinical Frailty Scale (CFS) score (OR 2.08, 95% CI 1.78-2.42), increased age (each 5 years of increase in age had a OR of 1.22 (95% CI 1.12-1.34) and SOFA score [OR of 1.07 (95% CI 1.05-1.09 per point)]. The frequency of LST limitation was higher in countries with high GDP and was lower in religious countries.<bold>Conclusions: </bold>The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country.<bold>Trial Registration: </bold>ClinicalTrials.gov (ID: NTC03134807).
- Subjects
HEALTH of older people; HOSPITAL admission &; discharge; INTENSIVE care units; MEDICAL decision making; LOGISTIC regression analysis; CLINICAL trials
- Publication
Intensive Care Medicine, 2018, Vol 44, Issue 7, p1027
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-018-5196-7