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- Title
Study on the mechanism of TMRK electroacupuncture in repairing synaptic plasticity in amygdala and hippocampus to relieve fear memory in PTSD rats.
- Authors
Li, Mi; Li, Kai; Zhang, Hong; Jiang, Yong; Gómez, Carlos; Schwarzacher, Severin P.
- Abstract
<bold>Background and Objective: </bold>Post-traumatic stress disorder (PTSD) is a chronic mental disorder caused by mental or psychological trauma after sudden events of a catastrophic or threatening nature. Synaptic plasticity is the core mechanism of PTSD and the main point of treatment of this disease.<bold>Methods: </bold>Male Sprague Dawley rats were randomly divided into blank control (Ctrl), SPS (single-prolonged stress) model, SPS&S model (SPS and foot electric shock), SPS+EA (SPS plus electroacupuncture), and SPS&S+EA groups. Tranquilize Mind and Regulate Kidney (TMRK) electroacupuncture method was performed in each rat in the SPS+EA and SPS&S+EA groups, the treatment lasted for 20 minutes per day, simultaneously for 3 consecutive weeks. Behavioral evaluations, molecular tests, electron microscopy, electrophysiological testing were conducted following the treatment.<bold>Results: </bold>First, electro-acupuncture can significantly improve the PTSD-like symptoms. Second, electro-acupuncture can up-regulate the long-term potentiation (LTP) in hippocampus, repair the synaptic morphology and improve BDNF levels in amygdala and hippocampus. Third, electroacupuncture can significantly up-regulate SYN, GAP43, and PSD95 protein levels and mRNA expression in amygdala and hippocampus.<bold>Conclusions: </bold>The effect of TMRK electro-acupuncture method on the regression of fear memory of PTSD rats may be through its repair of synaptic plasticity in amygdala and hippocampus.
- Subjects
FEAR; DIAGNOSIS of post-traumatic stress disorder; ELECTROACUPUNCTURE; NEUROPLASTICITY; AMYGDALOID body; ANIMAL experimentation; BASAL ganglia; ENZYME-linked immunosorbent assay; HIPPOCAMPUS (Brain); MEMORY; POLYMERASE chain reaction; POST-traumatic stress disorder; RATS; WESTERN immunoblotting
- Publication
Technology & Health Care, 2019, Vol 27, p425
- ISSN
0928-7329
- Publication type
journal article
- DOI
10.3233/THC-199038