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- Title
Psoriasis confined strictly to vitiligo areas – a Koebner-like phenomenon?
- Authors
Berger, T. G.; Kiesewetter, F.; Maczek, C.; Bauer, N.; Lueftl, M.; Schuler, G.; Simon, M.
- Abstract
Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre-existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T cells. By immunohistochemistry, intracytoplasmatic granzyme B and tumour necrosis factor alpha (TNF-α) were detected within the T-cell population, suggesting the functional activity of these cells and the creation of a local T helper 1 (Th1)-cytokine milieu. Additionally, in one patient we could identify anti-melanocytic T cells by tetramer staining and enzyme-linked immunospot (ELISPOT) analysis. These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-α and interferon-γ (IFN-γ), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis.
- Subjects
PSORIASIS; VITILIGO; PIGMENTATION disorders; IMMUNOREGULATION; TUMOR necrosis factors; SKIN diseases
- Publication
Journal of the European Academy of Dermatology & Venereology, 2006, Vol 20, Issue 2, p178
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2006.01354.x