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- Title
IGFBP7’s susceptibility to proteolysis is altered by A-to-I RNA editing of its transcript
- Authors
Godfried Sie, Christina; Hesler, Stephen; Maas, Stefan; Kuchka, Michael
- Abstract
Abstract: The selective deamination of adenosines (A) to inosines (I) in messenger RNAs (mRNAs) can alter the encoded protein’s amino acid sequence, with often critical consequences on protein stability, localization, and/or function. Insulin-like growth factor-binding protein 7 (IGFBP7) supports cell-adhesion and stimulates fibroblast proliferation with IGF and insulin. It exists in both proteolytically processed and unprocessed forms with altered cell-extracellular matrix interactions. Here we show that editing of IGFBP7 transcripts impacts the protein’s susceptibility to proteolytic cleavage, thus providing a means for a cell to modulate its functionality through A-to-I RNA editing. Structured summary of protein interactions: MT-SP1 cleaves IGFBP7 by protease assay (View interaction).
- Subjects
PROTEOLYSIS; RNA editing; GENETIC transcription; INSULIN-like growth factor-binding proteins; SERINE proteinases; PROTEIN structure; EXTRACELLULAR matrix proteins; PROTEIN-protein interactions
- Publication
FEBS Letters, 2012, Vol 586, Issue 16, p2313
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.06.037