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- Title
Increase in CIP2A expression is associated with doxorubicin resistance
- Authors
Choi, Yeon A.; Park, Jeong Su; Park, Mi Young; Oh, Ki Sook; Lee, Myung Sok; Lim, Jong-Seok; Kim, Keun Il; Kim, Kun-yong; Kwon, Junhye; Yoon, Do Young; Moon, Eun-Yi; Yang, Young
- Abstract
Abstract: The cancerous inhibitor of protein phosphatase 2A (CIP2A) increases the migration and metastasis of various cancer cells. Overexpression of CIP2A has been shown to increase the proliferation of MDA-MB-231 cells. We thus assessed whether CIP2A expression is associated with sensitivity to doxorubicin. MDA-MB-231 cells showed an increase in CIP2A expression after treatment with doxorubicin, while MCF-7 cells showed a decrease in CIP2A expression. The overexpression of CIP2A in MCF-7 cells overcame the inhibition of cell proliferation in response to doxorubicin treatment. CIP2A expression was not affected by wild-type or mutant p53. However, mutant p53 blocked doxorubicin-mediated CIP2A down-regulation in HCT116 cells. As a regulation mechanism of doxorubicin-mediated CIP2A expression, we showed that phosphorylated Akt was involved in the suppression of CIP2A expression.
- Subjects
DOXORUBICIN; GENE expression; PHOSPHATASES; CANCER cells; METASTASIS; CELL migration; CELL proliferation
- Publication
FEBS Letters, 2011, Vol 585, Issue 5, p755
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2011.01.018