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- Title
Genetic Variation in the RANKL/RANK/OPG Signaling Pathway Is Associated With Bone Turnover and Bone Mineral Density in Men.
- Authors
Roshandel, Delnaz; Holliday, Kate L.; Pye, Stephen R.; Boonen, Steven; Borghs, Herman; Vanderschueren, Dirk; Huhtaniemi, Ilpo T.; Adams, Judith E.; Ward, Kate A.; Bartfai, Gyorgy; Casanueva, Felipe; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Kula, Krzysztof; Lean, Michael E.; Pendleton, Neil; Punab, Margus; Silman, Alan J.
- Abstract
The article discusses a study which determined the link of genetic variation in the RANKL/RANK/OPG signaling pathway with bone turnover and bone mineral density (BMD) in men. The researchers selected pairwise tag single-nucleotide polymorphisms (SNPs) in RANKL, RANK and OPG and their flanking regions. The results of the study suggest that genetic variation in the RANKL/RANK/OPG signaling pathway has an effect on bone turnover and BMD in European men.
- Subjects
GENETIC polymorphism research; NUCLEOTIDES; BONE density; PHYSIOLOGY of men; RESEARCH
- Publication
Journal of Bone & Mineral Research, 2010, Vol 25, Issue 8, p1830
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.78