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- Title
Dynamics and Clinical Significance of Cytomegalovirus-Specific Neutralizing Antibodies in Kidney Transplant Recipients Treated with T-Cell–Depleting Agents.
- Authors
Fernández-Ruiz, Mario; García-Ríos, Estéfani; Redondo, Natalia; Rodríguez-Goncer, Isabel; Ruiz-Merlo, Tamara; Parra, Patricia; Sandonis, Virginia; López-Medrano, Francisco; Juan, Rafael San; González, Esther; Polanco, Natalia; Andrés, Amado; Navarro, David; Aguado, José María; Pérez-Romero, Pilar
- Abstract
We measured cytomegalovirus (CMV)-specific antibodies that neutralize epithelial cell infection (CMV-AbNEIs) in 101 CMV-seropositive kidney transplant recipients (KTRs) at baseline and posttransplant months 3 and 6. All the patients received antithymocyte globulin and 3-month valganciclovir prophylaxis. There were no significant differences in pretransplant AbNEIs titers between KTRs that developed or did not develop any-level CMV infection or the composite of high-level infection and/or disease. One-year CMV infection-free survival was comparable between KTRs with or without pretransplant CMV-AbNEIs. No differences were observed by months 3 and 6. We observed no protective role for CMV-AbNEIs among CMV-seropositive KTRs undergoing T-cell–depleting induction.
- Subjects
KIDNEY transplantation; IMMUNOGLOBULINS; CYTOMEGALOVIRUS diseases; EPITHELIAL cells; GLOBULINS
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 6, p1812
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad411