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- Title
Substantial Burden of Nonmedically Attended RSV Infection in Healthy-Term Infants: An International Prospective Birth Cohort Study.
- Authors
Hak, Sarah F; Venekamp, Roderick P; Billard, Marie-Noëlle; Houten, Marlies A van; Pollard, Andrew J; Heikkinen, Terho; Cunningham, Steve; Millar, Margaret; Martinón-Torres, Federico; Dacosta-Urbieta, Ana; Bont, Louis J; Wildenbeest, Joanne G; Investigators, PROMISE
- Abstract
Background During the first year of life, 1 in 4 infants develops a symptomatic respiratory syncytial virus (RSV) infection, yet only half seek medical attention. The current focus on medically attended RSV therefore underrepresents the true societal burden of RSV. We assessed the burden of nonmedically attended RSV infections and compared with medically attended RSV. Methods We performed active RSV surveillance until the age of 1 year in a cohort (n = 993) nested within the Respiratory Syncytial Virus Consortium in EUrope (RESCEU) prospective birth cohort study enrolling healthy term-born infants in 5 European countries. Symptoms, medication use, wheezing, and impact on family life were analyzed. Results For 97 of 120 (80.1%) nonmedically attended RSV episodes, sufficient data were available for analysis. In 50.5% (49/97), symptoms lasted ≥15 days. Parents reported impairment in usual daily activities in 59.8% (58/97) of episodes; worries, 75.3% (73/97); anxiety, 34.0% (33/97); and work absenteeism, 10.8% (10/93). Compared with medically attended RSV (n = 102, 9 hospital admissions), Respiratory Syncytial Virus NETwork (ReSViNET) severity scores were lower (3.5 vs 4.6, P <.001), whereas duration of respiratory symptoms and was comparable. Conclusions Even when medical attendance is not required, RSV infection poses a substantial burden to infants, families, and society. These findings are important for policy makers when considering the implementation of RSV immunization. Clinical Trials Registration. ClinicalTrials.gov (NCT03627572).
- Subjects
EUROPE; RESPIRATORY syncytial virus infections; COHORT analysis; RESPIRATORY syncytial virus; INFANTS; CLINICAL trial registries
- Publication
Journal of Infectious Diseases, 2024, Vol 229, pS40
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad477