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- Title
Proper assignation of reactivation in a COVID-19 recurrence initially interpreted as a reinfection.
- Authors
Pérez-Lago, Laura; Martínez-Lozano, Helena; Díaz, Jose Antonio Pajares; Gómez, Arantxa Díaz; Machado, Marina; Sola-Campoy, Pedro J; Herranz, Marta; Buenestado-Serrano, Sergio; Valerio, Maricela; Olmedo, María; Zayas, Cristina Andrés; Comas, Iñaki; Candelas, Fernando González; Bañares, Rafael; Catalán, Pilar; Muñoz, Patricia; Viedma, Darío García de; Pajares Díaz, Jose Antonio; Díaz Gómez, Arantxa; Andrés Zayas, Cristina
- Abstract
A 77-year-old-male (Case R) who had had a previous diagnosis of mild COVID-19 episode, was hospitalized 35 days later. On Day 23 post-admission, he developed a second COVID-19 episode, now severe, and finally died. Initially, Case R COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR-positive room-mate. However, whole-genome-sequencing indicated that case R recurrence corresponded to a reactivation of the strain involved in his first episode. Case R reactivation had major consequences, leading to a more severe episode, and causing a subsequent transmission to another two hospitalized patients, one of them with fatal outcome.
- Subjects
COVID-19; REINFECTION; COVID-19 pandemic; SARS-CoV-2; COVID-19 testing
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 5, p788
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab302