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- Title
Challenges of Discrepant HIV Tests in Pregnant Women in the PrEP era-to Treat or Not to Treat?
- Authors
Wagner, Anjuli D; Kinuthia, John; Dettinger, Julia; Mwongeli, Nancy; Gómez, Laurén; Watoyi, Salphine; Drake, Alison L; Abuna, Felix; Pintye, Jillian; Ochieng, Ben; Odinga, Daniel; John-Stewart, Grace; Baeten, Jared M; GÓmez, Laurén
- Abstract
<bold>Background: </bold>During HIV retesting in antenatal and preexposure prophylaxis (PrEP) care, discrepant results occur, but guidelines are lacking.<bold>Methods: </bold>In a Kenyan trial implementing antenatal PrEP, if 1 test is reactive, a second is performed; if discrepant, both are repeated; if persistently discrepant, DNA polymerase chain reaction (PCR) is performed.<bold>Results: </bold>Among 4451 women, 23 265 HIV retesting sessions were performed; 14 (0.06%, 95% confidence interval, 0.03%-0.10%) had discrepant results among 10 individuals; in all 10 initial cases, PCR was negative.<bold>Conclusions: </bold>Discrepant rapid tests are an expected, rare, and important challenge for antenatal care HIV retesting, with and without PrEP.<bold>Clinical Trials Registration: </bold>NCT03070600.
- Subjects
KENYA; PREGNANT women; CLINICAL trial registries; HIV; DNA polymerases; POLYMERASE chain reaction; DIAGNOSIS of HIV infections; COMMUNICABLE disease diagnosis; HIV prevention; PREVENTION of communicable diseases; HIV infections; ANTI-HIV agents; COMMUNICABLE diseases; MEDICAL screening; PREVENTIVE health services; HIGHLY active antiretroviral therapy; PREGNANCY complications; RESEARCH funding; PRENATAL care; DISEASE management
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 2, p234
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa343