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- Title
Decrease of stimulated amylin release precedes impairment of insulin secretion in type II diabetes.
- Authors
Ludvik, Bernhard; Lell, Bert; Hartter, Engelbert; Schnack, Christoph; Prager, Rudolf; Ludvik, B; Lell, B; Hartter, E; Schnack, C; Prager, R
- Abstract
Amylin, a 37-amino acid polypeptide, has been identified as the major protein component of pancreatic amyloid deposits in patients with non-insulin-dependent (type II) diabetes mellitus. Amylin is stored and released together with insulin and has been proposed to play a major role in the pathogenesis of type II diabetes. To compare amylin release and its proportion to insulin secretion under different metabolic conditions, oral and intravenous glucose tolerance tests (OGTT and IVGTT, respectively) were performed in healthy, lean control subjects, obese patients with normal and impaired glucose tolerance (NGT and IGT, respectively), and obese type II diabetic patients. Compared with control subjects, basal and stimulated amylin secretion during OGTT was significantly higher in obese patients with NGT and IGT but not in type II diabetic patients. The integrated amylin response was significantly higher in obese patients with NGT than lean control subjects and type II diabetic patients matched for degree of obesity. The amylin-insulin ratio decreased slightly in obese subjects with NGT and IGT and significantly in type II diabetic patients. Amylin secretion was significantly stimulated during IVGTT in control subjects and obese patients with NGT and IGT but not in type II diabetic patients. These findings suggest that amylin is physiologically released by pancreatic beta-cells in a constant ratio to insulin in nondiabetic subjects. Glucose-stimulated amylin secretion is increased in obese subjects with NGT and IGT. In type II diabetes mellitus, amylin secretion relative to that of insulin is decreased, and amylin is not stimulated by IVGTT.
- Subjects
PROTEIN metabolism; BLOOD sugar; DYNAMICS; GLUCOSE tolerance tests; INSULIN; TYPE 2 diabetes; OBESITY; PREDIABETIC state; PROTEINS; RADIOIMMUNOASSAY; REFERENCE values; TIME; PANCREATIC hormones
- Publication
Diabetes, 1991, Vol 40, Issue 12, p1615
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.40.12.1615