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- Title
Pre-synaptic adenosine A.
- Authors
Martire, Alberto; Tebano, Maria Teresa; Chiodi, Valentina; Ferreira, Samira G.; Cunha, Rodrigo A.; Köfalvi, Attila; Popoli, Patrizia
- Abstract
An interaction between adenosine A2A receptors (A2ARs) and cannabinoid CB1 receptors (CB1Rs) has been consistently reported to occur in the striatum, although the precise mechanisms are not completely understood. As both receptors control striatal glutamatergic transmission, we now probed the putative interaction between pre-synaptic CB1R and A2AR in the striatum. In extracellular field potentials recordings in corticostriatal slices from Wistar rats, A2AR activation by CGS21680 inhibited CB1R-mediated effects (depression of synaptic response and increase in paired-pulse facilitation). Moreover, in superfused rat striatal nerve terminals, A2AR activation prevented, while A2AR inhibition facilitated, the CB1R-mediated inhibition of 4-aminopyridine-evoked glutamate release. In summary, the present study provides converging neurochemical and electrophysiological support for the occurrence of a tight control of CB1R function by A2ARs in glutamatergic terminals of the striatum. In view of the key role of glutamate to trigger the recruitment of striatal circuits, this pre-synaptic interaction between CB1R and A2AR may be of relevance for the pathogenesis and the treatment of neuropsychiatric disorders affecting the basal ganglia.
- Subjects
ADENOSINES; CANNABINOIDS; NEURAL transmission; GLUTAMIC acid; DOPAMINE
- Publication
Journal of Neurochemistry, 2011, Vol 116, Issue 2, p273
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/j.1471-4159.2010.07101.x