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- Title
Fufang Xueshuantong for Diabetic Kidney Disease: A Systematic Review and Meta-Analysis.
- Authors
Tan, Yu-meng; Hu, Jun; Wu, Qian; Zhang, Yi; Suo, Wen-dong; Zhou, Yu-tong; Guo, He; Ni, Qing
- Abstract
Objective.tempspacetempspaceThe objective of this meta-analysis was to systematically assess the efficacy and safety of patented Chinese medicine Fufang Xueshuantong (FFXST) for the treatment of diabetic kidney disease (DKD).tempspacetempspaceMethods.tempspacetempspaceRandomized controlled trials (RCTs) of FFXST for DKD treatment were searched until May 31, 2020, in seven electronic databases: PubMed, Embase, Cochrane Library, CNKI, Wanfang, VIP, and Chinese Biomedical Literature.tempspacetempspaceThe Cochrane risk test from the Cochrane Handbook was used as a bias tool to assess the methodological quality, and Review Manager (RevMan) 5.3 was used to analyze the results.tempspacetempspaceGrading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were used to classify the quality of evidence.tempspacetempspaceResults.tempspacetempspaceThirteen RCTs involving 1,186 patients were included.tempspacetempspaceThe meta-analysis revealed that the efficacy of FFXST in treatment of DKD was significantly superior to that of the control treatment (P = 0. 0006).tempspacetempspaceThe urinary albumin excretion rate (P < 0.01), urinary albumin creatinine ratio (P < 0.0001), and microalbumin (P < 0.0001) were lower in the treatment groups than in the control group.tempspacetempspaceThere was also a decrease in low-density lipoprotein cholesterol (P < 0.0001), serum triglyceride (P = 0.001), and C-reactive protein (P < 0.0001) in the treatment groups compared with those in the control group.tempspacetempspaceNo significant difference in hemoglobin A1c level (P = 0.76) and systolic blood pressure (P = 0.34) was noted between the treatment and control groups.tempspacetempspaceThree studies reported adverse events, including dizziness and intolerance.tempspacetempspaceIn the other 10 trials, adverse events were not mentioned.tempspacetempspaceConclusion.tempspacetempspaceFFXST appears to be effective in the treatment of DKD.tempspacetempspaceHowever, the low methodological quality of the RCTs suggests that larger, better-designed RCTs are required to verify the clinical effectiveness and safety of FFXST.
- Subjects
BLOOD pressure; C-reactive protein; CREATINE; DIABETIC nephropathies; DIZZINESS; GLYCOSYLATED hemoglobin; HERBAL medicine; INFORMATION storage &; retrieval systems; MEDICAL databases; MEDICAL information storage &; retrieval systems; LOW density lipoproteins; CHINESE medicine; MEDLINE; META-analysis; ONLINE information services; TRIGLYCERIDES; SYSTEMATIC reviews; PLANT extracts; ALBUMINS; TREATMENT effectiveness; GLUCOSE intolerance; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2020, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2020/9326948