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- Title
The human immune response to Toxoplasma: Autophagy versus cell death.
- Authors
Krishnamurthy, Shruthi; Konstantinou, Eleni K.; Young, Lucy H.; Gold, Daniel A.; Saeij, Jeroen P. J.
- Abstract
The article focuses on mechanisms of Toxoplasma clearance by human cells such as autophagy and cell death and human immune response. Topics discussed include cytokine interferon gamma (IFNγ) induces multiple toxoplasmacidal mechanisms, Toll-like receptors 11/12 (TLR11/12) found in mice that bind to the Toxoplasma protein profilin and trigger a signaling cascade leading to the production of interleukin 12 and humans also lack the multitude of murine immunity-related GTPases (IRGs).
- Subjects
TOXOPLASMA; AUTOPHAGY; CELL death; IMMUNE response; INTERFERON gamma; PROFILIN; INTERLEUKIN-12
- Publication
PLoS Pathogens, 2017, Vol 13, Issue 3, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1006176