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- Title
Vitamin D status of patients with early inflammatory arthritis.
- Authors
Park, Young-Eun; Kim, Bo-Hyun; Lee, Seung-Geun; Park, Eun-Kyung; Park, Ji-Heh; Lee, Sun-Hee; Kim, Geun-Tae
- Abstract
The present study aimed to investigate the vitamin D status in patients with early inflammatory arthritis (EIA). We conducted a retrospective study among patients who presented with EIA at the outpatient rheumatology clinic of a tertiary referral center between March 2012 and February 2013. In total, 101 subjects with EIA (≥1 swollen joint and symptom duration of ≤6 months, not explained by another disease) and 101 healthy controls matched for age, sex, and the month of serum vitamin D measurements were enrolled. Serum 25-hydroxy vitamin D (25-OHD) concentrations were assessed by radioimmunoassay. Vitamin D 'deficiency' and 'severe deficiency' were defined as serum 25-OHD levels <20 and <10 ng/mL, respectively. Among EIA patients, rheumatoid arthritis (RA) was classified according to the 2010 American College of Rheumatology/European League against Rheumatism criteria. Vitamin D deficiency was highly prevalent among EIA patients, but no significant differences in the frequency of vitamin D deficiency of EIA patients and controls were observed (75.2 vs 65.3 %, p = 0.106). Additionally, in spring and summer, EIA patients had significantly lower serum 25-OHD concentrations than controls, but the opposite trend was observed in autumn. Among 101 EIA patients, 38 (37.1 %) were classified as having RA. Severe vitamin D deficiency in EIA patients was significantly associated with the higher likelihood of being classified as having RA. In conclusion, the frequency of vitamin D deficiency in EIA patients was comparable to that in controls, but severe vitamin D deficiency was associated with the presence of RA among EIA patients.
- Subjects
VITAMIN D in the body; VITAMIN D deficiency; RHEUMATOID arthritis; DIET in disease; ARTHRITIS; DIAGNOSIS; NUTRITION
- Publication
Clinical Rheumatology, 2015, Vol 34, Issue 2, p239
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-014-2613-3