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- Title
Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study.
- Authors
Noda, H.; Iso, H.; Irie, F.; Sairenchi, T.; Ohtaka, E.; Ohta, H.
- Abstract
Noda H, Iso H, Irie F, Sairenchi T, Ohtaka E, Ohta H (Osaka University, Osaka, Japan; Harvard School of Public Health, Cambridge, MA, USA; Ibaraki Prefectural Office, Ibaraki; Dokkyo Medical University School of Medicine, Tochigi; Ibaraki Health Service Association, Ibaraki; Japan). Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study. J Intern Med 2010; 267:576–587. Objective. The aim of this study was to examine whether LDL cholesterol raises the risk of coronary heart disease in a dose–response fashion in a population with low LDL-cholesterol levels. Design. Population-based prospective cohort study in Japan. Subjects and main outcome measures. A total of 30 802 men and 60 417 women, aged 40 to 79 years with no history of stroke or coronary heart disease, completed a baseline risk factor survey in 1993. Systematic mortality surveillance was performed through 2003 and 539 coronary heart disease deaths were identified. Results. The mean values for LDL-cholesterol were 110.5 mg dL−1 (2.86 mmol L−1) for men and 123.9 mg dL−1 (3.20 mmol L−1) for women. Men with LDL-cholesterol ≥140 mg dL−1 (≥3.62 mmol L−1) had two-fold higher age-adjusted risk of mortality from coronary heart disease than did those with LDL-cholesterol <80 mg dL−1 (<2.06 mmol L−1), whereas no such association for women was found. The multivariable hazard ratio for the highest versus lowest categories of LDL-cholesterol was 2.06 (95 percent confidence interval: 1.34 to 3.17) for men and 1.16 (0.64 to 2.12) for women. Conclusion. Higher concentrations of LDL-cholesterol were associated with an increased risk of mortality from coronary heart disease for men, but not for women, in a low cholesterol population.
- Subjects
JAPAN; CORONARY disease; LOW density lipoproteins; LOW-cholesterol diet; MORTALITY; SEX differences (Biology)
- Publication
Journal of Internal Medicine, 2010, Vol 267, Issue 6, p576
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1111/j.1365-2796.2009.02183.x