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- Title
Cyclooxygenase-2 Expression in Cervical Intraepithelial Neoplasia.
- Authors
Kim, Kidong; Jeon, Yong‐Tark; Park, In‐Ae; Kim, Jae Weon; Park, Noh‐Hyun; Kang, Soon‐Beom; Lee, Hyo‐Pyo; Song, Yong‐Sang
- Abstract
To evaluate the role of cyclooxygenase (COX)-2 during cervical carcinogenesis, we investigated COX-2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX-2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX-2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX-2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX-2 expression was negative in all specimens. The COX-2 expression in dysplastic epithelium was higher in older ( P= 0.038) or postmenopausal ( P= 0.025) women. In conclusion, COX-2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX-2 expression in dysplastic epithelium was associated with age and menopausal status.
- Subjects
EPITHELIUM; CILIA &; ciliary motion; GENETIC toxicology; PARAFFIN wax; CARCINOGENESIS
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1171, p111
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2009.04724.x