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- Title
IL-7 Modulates Osteoclastogenesis in Patients Affected by Solid Tumors.
- Authors
ROATO, ILARIA; GORASSINI, EVA; BRUNETTI, GIACOMINA; GRANO, MARIA; CIUFFREDA, LIBERO; MUSSA, ANTONIO; FERRACINI, RICCARDO
- Abstract
High levels of interleukin-7 (IL-7) have been associated with bone loss due to its stimulatory osteoclastogenic activity. Osteolytic patients' peripheral blood mononuclear cells (PBMCs) differentiate into osteoclasts without adding stimulating factors. Now, we investigated the potential role of IL-7 in the spontaneous osteoclastogenesis occurring in these patients. We identified significant differences in serum IL-7 levels between patients with/without bone metastases, suggesting that IL-7 might be effective as a clinical marker of disease progression. In patients' PBMC cultures we demonstrated that IL-7 stimulates osteoclastogenesis by inducing TNF-α release by T and B cells. These findings add further details to the disclosure of the mechanisms controlling bone metastases in solid tumors.
- Subjects
BONE growth; HUMAN growth hormone; BONE density; SKELETAL maturity; MUSCULOSKELETAL system; HUMAN body composition; HUMAN body; CLINICAL medicine; MEDICAL research
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1117, p377
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1402.002