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- Title
Can PACAP-38 Modulate Immune and Endocrine Responses During Lipopolysaccharide (LPS)-Induced Acute Inflammation?
- Authors
BARANOWSKA‐BIK, AGNIESZKA; BIK, WOJCIECH; WOLINSKA‐WITORT, EWA; CHMIELOWSKA, MAGDALENA; MARTYNSKA, LIDIA; BARANOWSKA, BOGUSLAWA
- Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) shows a potential anti-inflammatory activity and interacts with the endocrine system. The aim of the present article was to evaluate the effects of PACAP38 on the endocrine and immune systems during acute inflammation. Rats used in the experiments, divided into four groups, were given intraperitoneal injection of, respectively 0.9% NaCl, LPS, PACAP38, and LPS+PACAP38. Hormone (pituitary, adrenal, and thyroid) and cytokine (TNF-α, IL-6, IL10) concentrations were measured 2 and 4 h after the injection. Treatment with LPS + PACAP, as compared to LPS, caused TNF-α and corticosterone to decrease and T4 to increase after 2 h. These data suggest that PACAP modulates both the endocrine and immune responses in this model of septic shock.
- Subjects
IMMUNE response; PEPTIDE hormones; IMMUNE system; CORTICOSTERONE; SEPTIC shock
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1070, Issue 1, p156
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1317.004