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- Title
Processing Advanced Glycation End Product--Modified Albumin by the Renal Proximal Tubule and the Early Pathogenesis of Diabetic Nephropathy.
- Authors
OZDEMIR, AYLIN M.; HOPFER, ULRICH; ERHARD, PENNY; MONNIER, VINCENT M.; WEISS, MIRIAM F.
- Abstract
Diabetes is characterized by increased quantities of circulating proteins modified by advanced glycation end products (AGEs). Proteins filtered at the glomerulus and presented to the renal proximal tubule are likely to be highly modified by AGEs. The proximal tubule binds, takes up, and catabolizes AGE-modified albumin by pathways different from those of unmodified albumin. These differences were examined in polarized, electrically resistant proximal tubular cells grown in monolayer culture. In patients with type 1 diabetes, urinary excretion of a lysosomal enzyme predicted the development of nephropathy.
- Subjects
DIABETIC nephropathies; DIABETES complications; KIDNEY diseases; CARBOHYDRATE intolerance; PROTEINS; PEOPLE with diabetes
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1043, Issue 1, p625
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1338.071