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- Title
Cleaved Iron Oxide Nanoparticles as T<sub>2</sub> Contrast Agents for Magnetic Resonance Imaging.
- Authors
Jeon, Sung Lan; Chae, Min Kyung; Jang, Eun Ju; Lee, Chulhyun
- Abstract
Iron oxide nanoparticles as contrast agents are reported to effectively improve magnetic resonance imaging of tissues and cells. In this work, cleaved iron oxide nanoparticles (CIONPs) were generated from hydrophobic FeO nanoparticles (HIONPs) by coating their surfaces with PEG-phospholipids, oxidizing them under water, and slowly removing the residual FeO phase in phthalate buffer. The synthesized CIONPs showed good r2 values of up to 258 s−1 m M−1. Thus, the CIONPs can be employed as vectors for drug delivery due to their unique structure with an empty inner space, which enables their use in a wide range of applications.
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 13, p4217
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201201031