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- Title
Synthesis, characterization, and anticancer activity of ferrocenyl complexes bearing different organopalladium fragments.
- Authors
Scattolin, Thomas; Moro, Giulia; Serena, Anita; Guadagnin Pattaro, Alessia; Rizzolio, Flavio; Canzonieri, Vincenzo; Demitri, Nicola; Bortolamiol, Enrica; Moretto, Ligia Maria; Visentin, Fabiano
- Abstract
A straightforward synthetic route to a selection of new ferrocenyl complexes bearing different organopalladium fragments is reported. The target complexes were fully characterized by Nuclear Magnetic Resonance, High Resolution Mass Spectrometry, Infrared Spectroscopy, X‐ray Diffraction, and electrochemical techniques. All compounds, with the exception of Pd(0)‐olefin derivatives, showed excellent antitumor activity on ovarian cancer cells and, in the case of Pd (II)‐allyl and Pd (II)‐butadienyl complexes, a lower cytotoxicity towards normal cells.
- Subjects
ANTINEOPLASTIC agents; NUCLEAR magnetic resonance; MASS spectrometry; INFRARED spectroscopy; OVARIAN cancer
- Publication
Applied Organometallic Chemistry, 2022, Vol 36, Issue 5, p1
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.6629