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- Title
Cardiac MR elastography for quantitative assessment of elevated myocardial stiffness in cardiac amyloidosis.
- Authors
Arani, Arvin; Arunachalam, Shivaram P.; Chang, Ian C.Y.; Baffour, Francis; Rossman, Phillip J.; Glaser, Kevin J.; Trzasko, Joshua D.; McGee, Kiaran P.; Manduca, Armando; Grogan, Martha; Dispenzieri, Angela; Ehman, Richard L.; Araoz, Philip A.
- Abstract
<bold>Purpose: </bold>To evaluate if cardiac magnetic resonance elastography (MRE) can measure increased stiffness in patients with cardiac amyloidosis. Myocardial tissue stiffness plays an important role in cardiac function. A noninvasive quantitative imaging technique capable of measuring myocardial stiffness could aid in disease diagnosis, therapy monitoring, and disease prognostic strategies. We recently developed a high-frequency cardiac MRE technique capable of making noninvasive stiffness measurements.<bold>Materials and Methods: </bold>In all, 16 volunteers and 22 patients with cardiac amyloidosis were enrolled in this study after Institutional Review Board approval and obtaining formal written consent. All subjects were imaged head-first in the supine position in a 1.5T closed-bore MR imager. 3D MRE was performed using 5 mm isotropic resolution oblique short-axis slices and a vibration frequency of 140 Hz to obtain global quantitative in vivo left ventricular stiffness measurements. The median stiffness was compared between the two cohorts. An octahedral shear strain signal-to-noise ratio (OSS-SNR) threshold of 1.17 was used to exclude exams with insufficient motion amplitude.<bold>Results: </bold>Five volunteers and six patients had to be excluded from the study because they fell below the 1.17 OSS-SNR threshold. The myocardial stiffness of cardiac amyloid patients (median: 11.4 kPa, min: 9.2, max: 15.7) was significantly higher (P = 0.0008) than normal controls (median: 8.2 kPa, min: 7.2, max: 11.8).<bold>Conclusion: </bold>This study demonstrates the feasibility of 3D high-frequency cardiac MRE as a contrast-agent-free diagnostic imaging technique for cardiac amyloidosis.<bold>Level Of Evidence: </bold>2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1361-1367.
- Subjects
AMYLOIDOSIS; ECHOCARDIOGRAPHY; ELASTICITY; HEART; HEART ventricles; DIGITAL image processing; MAGNETIC resonance imaging; MYOCARDIUM; PATIENT positioning; ULTRASONIC imaging; CONTRAST media; CASE-control method
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 5, p1361
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25678