We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres.
- Authors
Mattio, Luce Micaela; Pinna, Cecilia; Catinella, Giorgia; Musso, Loana; Pedersen, Kasandra Juliet; Krogfelt, Karen Angeliki; Dallavalle, Sabrina; Pinto, Andrea
- Abstract
The natural stilbenoid dehydro-δ-viniferin, containing a benzofuran core, has been recently identified as a promising antimicrobial agent. To define the structural elements relevant to its activity, we modified the styryl moiety, appended at C5 of the benzofuran ring. In this paper, we report the construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed us to prepare a focused collection of dehydro-δ-viniferin analogues. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analogue 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4 µg/mL).
- Subjects
ANTI-infective agents; CHEMICAL synthesis; BENZOFURAN; MOIETIES (Chemistry)
- Publication
Molecules, 2021, Vol 26, Issue 24, p7594
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26247594