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- Title
New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles.
- Authors
Vlad, Ilinca Margareta; Nuță, Diana Camelia; Ancuceanu, Robert Viorel; Caproiou, Miron Teodor; Dumitrascu, Florea; Marinas, Ioana Cristina; Chifiriuc, Mariana Carmen; Măruţescu, Luminita Gabriela; Zarafu, Irina; Papacocea, Ioana Raluca; Vasile, Bogdan Ștefan; Nicoară, Adrian Ionuț; Ilie, Cornelia-Ioana; Ficai, Anton; Limban, Carmen; Iriti, Marcello; Grande, Rossella
- Abstract
Antimicrobial resistance is one of the major public health threats at the global level, urging the search for new antimicrobial molecules. The fluorene nucleus is a component of different bioactive compounds, exhibiting diverse pharmacological actions. The present work describes the synthesis, chemical structure elucidation, and bioactivity of new O-aryl-carbamoyl-oxymino-fluorene derivatives and the contribution of iron oxide nanoparticles to enhance the desired biological activity. The antimicrobial activity assessed against three bacterial and fungal strains, in suspension and biofilm growth state, using a quantitative assay, revealed that the nature of substituents on the aryl moiety are determinant for both the spectrum and intensity of the inhibitory effect. The electron-withdrawing inductive effect of chlorine atoms enhanced the activity against planktonic and adhered Staphylococcus aureus, while the +I effect of the methyl group enhanced the anti-fungal activity against Candida albicans strain. The magnetite nanoparticles have substantially improved the antimicrobial activity of the new compounds against planktonic microorganisms. The obtained compounds, as well as the magnetic core@shell nanostructures loaded with these compounds have a promising potential for the development of novel antimicrobial strategies.
- Subjects
IRON oxide nanoparticles; INDUCTIVE effect; BIOACTIVE compounds; METHYL groups; MAGNETIC traps; IRON oxides; CHEMICAL structure
- Publication
Molecules, 2021, Vol 26, Issue 10, p3002
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26103002