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- Title
Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil.
- Authors
Barros, Luiz Marivando; Duarte, Antonia Eliene; Morais-Braga, Maria Flaviana Bezerra; Pansera Waczuk, Emily; Vega, Celeste; Leite, Nadghia Figueiredo; de Menezes, Irwin Rose Alencar; Melo Coutinho, Henrique Douglas; Rocha, João Batista Teixeira; Kamdem, Jean Paul
- Abstract
Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography-mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.
- Subjects
DRUG resistance; TRYPANOSOMIASIS treatment; PARASITIC disease treatment; LANTANA camara; HERBAL medicine
- Publication
Molecules, 2016, Vol 21, Issue 2, p209
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21020209