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- Title
Transcriptome analysis of primary chicken cells infected with infectious bronchitis virus strain K047-12 isolated in Korea.
- Authors
Lee, Rangyeon; Jung, Ji Seung; Yeo, Ji-in; Kwon, Hyuk Moo; Park, Jeongho
- Abstract
Infectious bronchitis virus (IBV), an avian coronavirus, is highly contagious. Chickens with IBV infection develop acute pathogenesis in multiple organs, including the respiratory and urogenital tracts. Frequent recombination in the spike (S) glycoprotein gene has made vaccine strategies ineffective. To understand IBV pathogenesis, we analyzed the genetic distance between Korean IBV isolates and other coronaviruses, including SARS-CoV-2. To obtain comprehensive information about early immune responses such as innate cytokine production and associated immune regulation during IBV infection, we infected primary chicken embryonic kidney cells and performed transcriptome analysis. We observed that the functional pathways of innate immunity are regulated and confirmed expression of genes that coordinate early immune responses. Understanding the immune profile of the host cell may assist in vaccine development.
- Subjects
SOUTH Korea; AVIAN infectious bronchitis virus; PRIMARY cell culture; GENETIC distance; SARS-CoV-2; CHICKEN embryos; VACCINE development; COVID-19
- Publication
Archives of Virology, 2021, Vol 166, Issue 8, p2291
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-021-05124-9