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- Title
Nanoparticle vaccines against viral infections.
- Authors
Sulczewski, Fernando B.; Liszbinski, Raquel B.; Romão, Pedro R. T.; Rodrigues Junior, Luiz Carlos
- Abstract
Despite numerous efforts, we still do not have prophylactic vaccines for many clinically relevant viruses, such as HIV, hepatitis C virus, Zika virus, and respiratory syncytial virus. Several factors have contributed to the current lack of effective vaccines, including the high rate of viral mutation, low immunogenicity of recombinant viral antigens, instability of viral antigenic proteins administered in vivo, sophisticated mechanisms of viral immune evasion, and inefficient induction of mucosal immunity by vaccine models studied to date. Some of these obstacles could be partially overcome by the use of vaccine adjuvants. Nanoparticles have been intensively investigated as vaccine adjuvants because they possess chemical and structural properties that improve immunogenicity. The use of nanotechnology in the construction of immunization systems has developed into the field of viral nanovaccinology. The purpose of this paper is to review and correlate recent discoveries concerning nanoparticles and specific properties that contribute to the immunogenicity of viral nanoparticle vaccines, bio-nano interaction, design of nanoparticle vaccines for clinically relevant viruses, and future prospects for viral nanoparticle vaccination.
- Subjects
NANOPARTICLES; VIRAL vaccines; NANOTECHNOLOGY; RESPIRATORY syncytial virus; IMMUNOLOGICAL adjuvants; THERAPEUTICS
- Publication
Archives of Virology, 2018, Vol 163, Issue 9, p2313
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-018-3856-0