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- Title
Effects of Afobazole on Cognitive Behavior of the Offspring of Rats Exposed to Tobacco Smoke during Gestation Period.
- Authors
Shreder, O. V.; Solomina, A. S.; Tsorin, I. B.; Trofimov, S. S.; Durnev, A. D.; Seredenin, S. B.
- Abstract
Experiments on the model of foraging behavior formation under conditions of free choice (T-maze) revealed learning failure against the background of reduced motor activity in the offspring of rats exposed to tobacco smoke on gestation days 1-20. Afobazole administered to pregnant rats orally in doses of 1 or 10 mg/kg daily during the whole gestation and/or entering rat pup body with breast milk from mothers receiving 200 mg/kg to day 20 of their life normalized their learning capacity. The formation of short-term and long-term memory in animals receiving afobazole did not differ from the control. Hence, afobazole corrects cognitive disorders in rats exposed to tobacco smoke during prenatal development.
- Subjects
MOTOR ability; LABORATORY rats; TOBACCO smoke; FORAGING behavior; PREGNANCY in animals
- Publication
Bulletin of Experimental Biology & Medicine, 2011, Vol 151, Issue 1, p41
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-011-1255-6