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- Title
Difference in immunohistochemical characteristics between Takayasu arteritis and giant cell arteritis: It may be better to distinguish them in the same age.
- Authors
Atsushi Kurata; Akira Saito; Hirotsugu Hashimoto; Koji Fujita; Shin-ichiro Ohno; Hiroshi Kamma; Toshitaka Nagao; Shigeto Kobayashi; Akira Yamashina; Masahiko Kuroda
- Abstract
Objectives: This study aimed to compare Takayasu arteritis (TAK) with giant cell arteritis (GCA) through immunohistochemistry principally of inflammatory cells; these two disorders may be on the spectrum within a single disease state. Methods: Nine TAK and 5 GCA surgically resected vessel specimens were selected. TAK specimen was divided into each three acute-, chronic-, and healed-phase samples based on intimal and adventitial thickening. Immunohistochemical analysis was performed of smooth muscle cells and inflammatory cells including lymphocytes, plasma cells, macrophages, and dendritic cells, where three healed-phase TAK specimens were excluded due to paucity of inflammation. Immunopositive cells per three different fields in intima, media, and adventitia were counted in each specimen, and their numbers in these three layers along with total 3 layers were compared between the two disorders. Results: Intimal smooth muscle maturity estimated by ratio of h-Caldesmonþ cells to a-SMAþ cells significantly increased in chronic- and healed-over acute-phase increases in TAK. Mann-Whitney tests demonstrated significantly more adventitial lymphoplasmacytic infiltration and less intimal fascinþ dendritic cells, as well as overall more CD8þ T-cells, more CD20þ B-cells and lower CD4/8 ratio in TAK than in GCA. Conclusion: Different inflammatory involvement is suggested in the pathogenesis of TAK and GCA.
- Subjects
TAKAYASU arteritis; GIANT cell arteritis; IMMUNOHISTOCHEMISTRY; PLASMA cells; LYMPHOCYTES
- Publication
Modern Rheumatology, 2019, Vol 29, Issue 6, p992
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1080/14397595.2019.1570999