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- Title
Direct Testing for KPC-Mediated Carbapenem Resistance from Blood Samples Using a T2 Magnetic Resonance Based Assay.
- Authors
De Angelis, Giulia; Paggi, Riccardo; Lowery, Thomas J.; Snyder, Jessica L.; Menchinelli, Giulia; Sanguinetti, Maurizio; Posteraro, Brunella; Mencacci, Antonella
- Abstract
Molecular-based carbapenem resistance testing in Gram-negative bacterial bloodstream infections (BSIs) is currently limited because of the reliance on positive blood culture (BC) samples. The T2Resistance™ panel may now allow the detection of carbapenemase- and other β-lactamase encoding genes directly from blood samples. We detected carbapenem resistance genes in 11 (84.6%) of 13 samples from patients with BC-documented BSIs (10 caused by KPC-producing Klebsiellapneumoniae and 1 caused by VIM/CMY-producing Citrobacter freundii). Two samples that tested negative for carbapenem resistance genes were from patients with BC-documented BSIs caused by KPC-producing K. pneumoniae who were receiving effective antibiotic therapy. In conclusion, our findings suggest that the T2Resistance™ panel can be a reliable tool for diagnosing carbapenem-resistant Gram-negative bacterial BSIs.
- Subjects
MAGNETIC resonance; BLOOD sampling; GRAM-negative bacterial diseases; CITROBACTER freundii; DIAGNOSIS
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 8, p950
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10080950