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- Title
Long Term Assessment of Anti-SARS-CoV-2 Immunogenicity after mRNA Vaccine in Persons Living with HIV.
- Authors
Vergori, Alessandra; Cozzi-Lepri, Alessandro; Matusali, Giulia; Cicalini, Stefania; Bordoni, Veronica; Meschi, Silvia; Mazzotta, Valentina; Colavita, Francesca; Fusto, Marisa; Cimini, Eleonora; Notari, Stefania; D'Aquila, Veronica; Lanini, Simone; Lapa, Daniele; Gagliardini, Roberta; Mariotti, Davide; Giannico, Giuseppina; Girardi, Enrico; Vaia, Francesco; Agrati, Chiara
- Abstract
(1) Background: Waning of neutralizing and cell-mediated immune response after the primary vaccine cycle (PVC) and the first booster dose (BD) is of concern, especially for PLWH with a CD4 count ≤200 cells/mm3. (2) Methods: Neutralizing antibodies (nAbs) titers by microneutralization assay against WD614G/Omicron BA.1 and IFNγ production by ELISA assay were measured in samples of PLWH at four time points [2 and 4 months post-PVC (T1 and T2), 2 weeks and 5 months after the BD (T3 and T4)]. Participants were stratified by CD4 count after PVC (LCD4, ≤200/mm3; ICD4, 201–500/mm3, and HCD4, >500/mm3). Mixed models were used to compare mean responses over T1–T4 across CD4 groups. (3) Results: 314 PLWH on ART (LCD4 = 56; ICD4 = 120; HCD4 = 138) were enrolled. At T2, levels of nAbs were significantly lower in LCD4 vs. ICD4/HCD4 (p = 0.04). The BD was crucial for increasing nAbs titers above 1:40 at T3 and up to T4 for WD614G. A positive T cell response after PVC was observed in all groups, regardless of CD4 (p = 0.31). (4) Conclusions: Waning of nAbs after PVC was more important in LCD4 group. The BD managed to re-establish higher levels of nAbs against WD614G, which were retained for 5 months, but for shorter time for Omicron BA.1. The T cellular response in the LCD4 group was lower than that seen in participants with higher CD4 count, but, importantly, it remained above detectable levels over the entire study period.
- Subjects
IMMUNE response; BOOSTER vaccines; CD4 lymphocyte count; MESSENGER RNA; T cells
- Publication
Vaccines, 2023, Vol 11, Issue 12, p1739
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11121739