We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The protective effect of phlorotannins from Sargassum naozhouense on bone loss in ovariectomized mice with hyperlipidemia.
- Authors
LI Yanping; CUI Liao; FENG Mi; LIU Yi
- Abstract
Objective To investigate the protective effect of phlorotannins from Sargassum naozhouense on bone loss in ovariectomized mice with hyperlipidemia. Methods Eighty female 4-week-old Kunming mice (20 -22 g) were randomly divided into 8 groups: Control, SHAM, OVX, OVX + P407, OVX + P407 + S, OVX + P407 + LP, OVX + P407 + MP, and OVX + P-407 + HP group. Mice in each group were given P-407 560mg/kg, i. p. every 3 days except in Control, SHAM, and OVX group. Phlorotannins of 125, 250, and 500mg/kg were given i. g. every day, respectively. The mice were sacrificed ninety days later, and the serum and bilateral femurs were collected. Results The concentrations of cholesterol, triglyceride, and low density lipoprotein in mice of remedy groups were lower than those in OVX + P-407 group (P < 0.05), and it was positively correlated with the concentration of phlorotannins. The decrease rate of triglyceride in phlorotannins treated groups was better than that in OVX + P-407 + S group (P < 0. 05). The concentration of malondialdehyde (MDA) in mice of OVX + P-407 group was higher than that in the other groups (P < 0. 05), but the superoxide dismutase (SOD) concentration in OVX + P-407 group was lower than that in the other groups (P < 0. 05). Both SOD and MDA concentration of the remedy groups were close to the blank control group (P > 0. 05). Biomechanical indexes in the femurs of OVX + P-407 group was significantly lower than those in the blank control group (P < 0. 05). The values of maximum load, rigidity coefficient, breaking load, the area under the maximum load curve, and breaking load curve in the remedy groups were higher than those in OVX + P-407 group. Among these indexes, the value of breaking load curve was significantly higher (P < 0.05 ). Conclusion Phlorotannins from sargassum naozhouense can protect bone loss in ovariectomized mice with hyperlipidemia by inhibiting oxidative stress in vivo.
- Publication
Chinese Journal of Osteoporosis, 2015, Vol 21, Issue 5, p586
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2015.05.014