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- Title
Presence of guanidinoacetate may compensate creatine absence and account for less statin-induced muscle damage in GAMT-deficient compared to AGAT-deficient mice.
- Authors
Balestrino, Maurizio; Adriano, Enrico
- Abstract
Dear Editor, We read with great interest the paper by Sasani et al. "Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure", which was recently published in Amino Acids (Sasani et al. [7]). This enzyme catalyzes the synthesis of guanidinoacetic acid from arginine and glycine, a reaction that represents the first step of creatine synthesis (Fig.
- Subjects
MUSCLES; MICE; GLYCINE; ADENOSINE diphosphate; CREATINE kinase; ASYMMETRIC dimethylarginine; AMINO acids
- Publication
Amino Acids, 2020, Vol 52, Issue 4, p667
- ISSN
0939-4451
- Publication type
Letter
- DOI
10.1007/s00726-020-02838-z