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- Title
Tualang and Kelulut Honey Reduced Lipopolysaccharides-stimulated Inflammatory Responses of Microglia.
- Authors
Low Zhao Xuan; Tan Kai Li; Yong Yoke Keong; Looi Chung Yeng; Ooi Yin Yin
- Abstract
Microglial activity is crucial in maintaining the central nervous system (CNS) homeostasis. However, prolonged microglial activation have been implicated in the pathology of neurodegenerative diseases. Activated microglia will increase the production of inflammatory cytokines, reactive oxygen species (ROS) and alter their surface marker expression levels. This study used Malaysian honey, Tualang honey (TH), and Kelulut honey (KH) to determine lipopolysaccharide (LPS)-stimulated inflammatory responses of microglia. TH and KH at 0.1% were used in the current study as our findings showed no significant difference in the cell viability between BV2 cells treated with 0.1 % of TH and KH and control group. TH and KH reduced the ROS level significantly by 41.62±1.06% and 49.16±0.63%, respectively, and slightly reduced the expression of co-stimulatory molecules, CD40 and CD11b in LPS-activated BV2 cells. Our preliminary findings proposed an in-depth future study on the anti-inflammatory effect of TH and KH on microglial activation.
- Subjects
INFLAMMATION; HONEY; MICROGLIA; REACTIVE oxygen species; CENTRAL nervous system
- Publication
Malaysian Journal of Medicine & Health Sciences, 2023, Vol 19, Issue 3, p375
- ISSN
1675-8544
- Publication type
Article
- DOI
10.47836/mjmhs18.5.47