We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Study on the roles of β-catenin in hydrogen peroxide-induced senescence in human skin fibroblasts.
- Authors
Li-ming Tian; Hong-fu Xie; Xiao Xiao; Ting Yang; Yao-hua Hu; Wei-zhen Wang; Lei-shan Liu; Xiang Chen; Ji Li
- Abstract
Oxidative stress is one of the most important causes of the cellular senescence process. Previous studies showed that β-catenin can regulate FoxO3a and this association was enhanced in cells exposed to oxidative stress. It has also been reported that β-catenin can regulate some senescence-related proteins. We propose that β-catenin may play a crucial role in senescence of normal human primary skin fibroblasts (NHSFs). Here, we explored the roles and mechanisms of β-catenin on H2O2-induced senescence in NHSFs. β-catenin expression was decreased in NHSFs after H2O2 treatment. Overexpression of β-catenin in NHSFs led to a marked delay of many senescent phenotypes induced by H2O2. Furthermore, overexpression of β-catenin in NHSFs can antagonise the alteration of reactive oxygen species accumulation and some senescence-related proteins expression induced by H2O2 treatment. Our data demonstrated that β-catenin can protect NHSFs from H2O2-induced premature senescence by alleviating oxidative stress and regulating some senescence-related molecules.
- Subjects
SKIN aging; CELLULAR aging; HYDROGEN peroxide; OXIDATIVE stress; FIBROBLASTS
- Publication
Experimental Dermatology, 2011, Vol 20, Issue 10, p836
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/j.1600-0625.2011.01324.x