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- Title
Use of an Emollient As a Steroid-Sparing Agent in the Treatment of Mild to Moderate Atopic Dermatitis in Children.
- Authors
Lucky, Anne W.; Leach, Alan D.; Laskarzewski, Peter; Wenck, Horst
- Abstract
The effectiveness of an emollient as an adjunct to topical corticosteroid therapy for the treatment of mild to moderate atopic dermatitis was studied for 3 weeks in 25 children 3 to 15 years of age in comparison with corticosteroid therapy alone. The adjunctive regimen of a once-daily application each of hydrocortisone 2.5% cream and of a water-in-oil cream was equivalent in efficacy to the comparative regimen of twice-daily applications of hydrocortisone 2.5% cream. Both treatment regimens elicited significant improvement in skin condition by day 7 (p < 0.005) and further significant improvement by day 14 (p < 0.005). No significant differences between the two treatment regimens were observed in the rates of improvement (p > 0.545) or in the reductions in mean lesion size (p > 0.98). No differences were observed in parental evaluations, except for ease of application where a slight preference was expressed for the hydrocortisone 2.5% cream preparation (p < 0.038). We conclude that emollient adjunctive therapy offers a steroid-sparing alternative to topical corticosteroids alone in the treatment of mild to moderate atopic dermatitis.
- Subjects
SKIN inflammation; HYDROCORTISONE; ALLERGIES; ATOPIC dermatitis; ADRENOCORTICAL hormones; SKIN diseases
- Publication
Pediatric Dermatology, 1997, Vol 14, Issue 4, p321
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/j.1525-1470.1997.tb00968.x